Figure 6
Microbiome co-occurrence in the AD within the four metagenomic groups. Correlation networks of significantly altered species based on the indicator species analysis. Spearman’s absolute correlation coefficients ≥ 0.5 and p-values < 0.05 were retained. The node size is proportional to the mean abundance of the species. Nodes are colored by taxonomy with labelled genera names. The positive correlation is represented by the green line, while the negative correlation is represented by the red line. The nodes were grouped according to their higher abundance in each group (It means that a species can be found in all or at least one group. But they were kept in such a group where it was highly abundant). The microbiomes of the AD showed positive associations between Groups I and II, while Groups III and IV showed negative correlations in terms of energy production with the microbial taxa of the other two groups. The R packages, Hmisc (https://cran.r-project.org/web/packages/Hmisc/index.html) package was used to analyze correlation and Gephi (https://gephi.org/) software was utilized to visualize the network plot.
