Table 5 LN+, DM and 5-year DSS according to combined PNI and LVI status.

From: Perineural invasion/lymphovascular invasion double positive predicts distant metastasis and poor survival in T3–4 oral squamous cell carcinoma

PNI/LVI status (n)

No (%) or rate

HR

95% CI

p

LN+*

     Double negative (37)

8 (21.6)

1

  

     Single positive (34)

15 (44.1)

2.86

1.02–8.06

0.046

     Double positive (27)

21 (77.8)

12.69

3.83–42.05

 < 0.001

DM*

     Double negative (37)

3 (8.1)

1

  

     Single positive (34)

5 (14.7)

1.95

0.43–8.89

0.386

     Double positive (27)

9 (33.3)

5.67

1.36–23.59

0.017

5-year DSS**

     Double negative (37)

86.7%

1

  

     Single positive (34)

73.7%

2.43

0.73–8.07

0.148

     Double positive (27)

44.3%

6.63

2.15–20.40

0.001

  1. PNI perineural invasion, LVI lymphovascular invasion, LN+ neck metastasis, DM distant metastasis, DSS disease-specific survival.
  2. *Binary logistic regression.
  3. **Cox proportional hazards model.
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