Figure 2

Gene Ontology Enrichment Analysis of Upregulated and Downregulated DEMs. Validated miRNA gene targets for differentially expressed miRNAs were separated into those associated with upregulated DEMs versus downregulated DEMs. GO-BP gene set enrichment analysis was then performed using miRnet built in hypergeometric testing. Significantly enriched (p value < 0.1) pathways of interest are depicted in the bar graphs above for gene targets of either (A) significantly upregulated or (B) significantly downregulated microRNAs. Numbers in parentheses for each pathway represent to number of identified gene targets associated with the GO-BP pathway term.