Figure 2 | Scientific Reports

Figure 2

From: Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways

Figure 2

Age-related changes in plasma metabolites reflect effects on purine metabolism in aged BAT. (a) Heatmap depicting plasma metabolite concentrations comparing plasma samples from young (2 months) to aged (15 months) mice that are significantly (p < 0.05) different between both age groups (n = 5 / group). All metabolites were detected by LC–MS and GC–MS metabolomic analysis. (b) Pathway identification analysis for polar and non-polar plasma metabolites with age-related changes using MetaboAnalyst software. Metabolites were selected based on significant (p < 0.05) differences between age groups. Tabular summary of all pathways identified from plasma metabolites, including pathways with significant enrichment (bold; p < 0.05), which were subsequently grouped into functionally related sub-clusters, i.e. (1) nutrient/ energy metabolism, (2) nucleotide metabolism, (3) vitamin metabolism, (4) lipid metabolism and (5) xenobiotic metabolism.

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