Figure 4
Polar metabolites involved in nucleotide metabolism correlate with BAT aging. Spearman correlations of individual polar metabolites linked to nucleotide metabolism that are significantly associated with aging (from left to right, top to bottom): Guanosine monophosphate (GMP), ribose-5´-phosphate, adenosine diphosphate-ribose (ADP-ribose), uridine monophosphate (UMP), uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), deoxyguanosine, and cytidine. Correlation coefficients (r) for individual metabolites were calculated to visualize age-dependent correlations of metabolic species. Individual peak intensities of all age groups were normalized to intensities measured in the 2.5 months control group. All data are depicted as mean ± SD (n = 3 for all groups); * p < 0.05 indicating significant correlation across all age groups; a, b, c, d p < 0.05 comparing relative intensity of the indicated age group compared to (a) 2.5 months, (b) 5 months, (c) 10 months or (d) 15 months, respectively, using two-tailed unpaired t-test.
