Figure 5 | Scientific Reports

Figure 5

From: Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways

Figure 5

mRNA expression of biosynthesis and degradation genes linked to metabolites identified in aged BAT. (a) mRNA levels of nutrient/ energy metabolism genes (see Suppl. Table S5 for full gene names) comparing BAT samples of young (2.5 months; n = 8; white bars) and aged (15 months; n = 7; grey bars) mice. (b) mRNA levels of nucleotide metabolism genes comparing BAT samples of young (2.5 months; n = 8; white bars) and old (15 months; n = 8; grey bars) mice. All genes are organized according to pathway enrichment in the proteome analysis of the same age groups (Table 1). Data are expressed as percentage of young (2.5 months) control. Data are shown as mean ± SD; *p < 0.05; **p < 0.01; ***p < 0.001 using non-parametric Mann–Whitney test.

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