Table 1 Clinicopathological characteristics of CRC patients, and the mRNA expression levels of genes.
From: AHA1 regulates cell migration and invasion via the EMT pathway in colorectal adenocarcinomas
Characteristics | No. of cases | mRNA expression of Aha1 (%) | mRNA expression of HSP90AA1 (%) | mRNA expression of HSP90AB1 (%) | |||
|---|---|---|---|---|---|---|---|
Median (range) | p-value | Median (range) | p-value | Median (range) | p-value | ||
Adjacent normal | 105 | 1.80 (± 0.27) | 0.032 | 5.17 (± 0.61) | < 0.001 | 3.44 (± 0.45) | 0.065 |
Colorectal cancer | 105 | 2.89 (± 0.42) | 12.50 (± 1.83) | 5.09 (± 0.76) | |||
Age (years) | 0.278 | 0.641 | 0.669 | ||||
≤ 60 | 28 | 3.65 (± 1.11) | 11.07 (± 2.66) | 4.54 (± 1.35) | |||
> 60 | 77 | 2.61 (± 0.42) | 13.02 (± 2.31) | 5.28 (± 0.92) | |||
Gender | 0.172 | 0.203 | 0.455 | ||||
Female | 39 | 3.64 (± 0.92) | 15.54 (± 3.34) | 5.83 (± 1.24) | |||
Male | 66 | 2.44 (± 0.39) | 10.70 (± 2.13) | 4.64 (± 0.98) | |||
Differentiation | 0.554 | 0.846 | 0.814 | ||||
Well | 29 | 2.20 (± 0.41) | 14.07 (± 4.23) | 5.86 (± 1.84) | |||
Moderate | 73 | 3.19 (± 0.58) | 11.79 (± 2.02) | 4.76 (± 0.83) | |||
Poorly | 3 | 1.99 (± 1.27) | 14.47 (± 11.75) | 5.47 (± 3.73) | |||
Location | 0.739 | 0.621 | 0.983 | ||||
Colon | 72 | 2.79 (± 0.44) | 11.88 (± 2.08) | 5.10 (± 1.01) | |||
Rectum | 33 | 3.09 (± 0.95) | 13.84 (± 3.68) | 5.06 (± 1.07) | |||
Size (cm) | 0.072 | 0.48 | 0.242 | ||||
≤ 6 | 77 | 2.42 (± 0.42) | 15.62 (± 2.26) | 7.20 (± 1.01) | |||
> 6 | 28 | 4.14 (± 1.08) | 12.15 (± 2.96) | 3.60 (± 0.66) | |||
TNM stage | 0.035 | 0.34 | 0.487 | ||||
I, II | 46 | 1.88 (± 0.28) | 14.49 (± 3.02) | 5.69 (± 1.27) | |||
III, IV | 59 | 3.67 (± 0.71) | 10.95 (± 2.25) | 4.61 (± 0.94) | |||
Lymp node | 0.012 | 0.6 | 0.745 | ||||
0 | 51 | 1.80 (± 0.26) | 13.49 (± 2.76) | 5.34 (± 1.15) | |||
1, 2 | 54 | 3.91 (± 0.77) | 11.56 (± 2.44) | 4.84 (± 1.02) | |||
Invasion | 0.199 | 0.253 | 0.252 | ||||
No | 85 | 2.62 (± 0.39) | 13.52 (± 2.21) | 5.51 (± 0.93) | |||
Yes | 20 | 4.01 (± 1.50) | 8.17 (± 1.82) | 3.27 (± 0.62) | |||
Metastasis | < 0.001 | 0.092 | 0.179 | ||||
No | 88 | 2.23 (± 0.26) | 13.85 (± 2.14) | 5.54 (± 0.90) | |||
Yes | 17 | 6.28 (± 2.10) | 5.49 (± 1.51) | 2.74 (± 0.65) | |||
