Table 1 Statistically significant associations of neurological conditions and severe disease status after admission (pFDR < 0.05).

From: Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19

Neurological condition (ICD-10 code)

LOEa

RRDb (%)

RRD

95% CI (%)

pFDR

Blindness and low vision (H54)

− 0.38

− 23

(− 33, − 11)

2.0 × 10–4

Dizziness and giddiness (R42)

− 0.47

− 28

(− 33, -22)

6.3 × 10–19

Encephalitis, myelitis and encephalomyelitis (G04)

0.45

37

(17, 60)

0.0081

Nontraumatic intracerebral hemorrhage (I61)

0.45

36

(23, 51)

3.6 × 10–5

Nontraumatic subarachnoid hemorrhage (I60)

0.35

28

(10, 48)

0.019

Other and unspecified myopathies (G72)

0.78

72

(67, 77)

8.8 × 10–45

Other and unspecified nontraumatic intracranial hemorrhage (I62)

0.43

34

(20, 50)

3.0 × 10–4

Other cerebrovascular diseases (I67)

0.31

24

(13, 35)

2.0 × 10–4

Other disorders of the brain (G93)

0.44

36

(32, 40)

5.6 × 10–73

Other headache syndromes (G44)

− 0.91

− 47

(− 59, − 31)

9.4 × 10–9

Other symptoms and signs involving cognitive functions and awareness (R41)

0.28

22

(19, 25)

2.1 × 10–39

Transient cerebral ischemic attacks and related syndromes (G45)

− 0.85

− 45

(− 56, − 31)

5.0 × 10–10

Unspecified psychosis not due to a substance or known physiological condition (F29)

− 0.84

− 44

(− 57, − 28)

7.7 × 10–8

  1. aThe interactive data table (https://covidclinical.github.io/Phase1.1NeuroRCode/01-analysis-icd10.html#enrichment_tab) and the results directory of the project online data repository (https://github.com/covidclinical/Phase1.1NeuroRCode/tree/master/results) show the log2 value of enrichment (LOE), 95% confidence intervals, and p values for all neurological ICD-codes adjusted for multiple hypothesis testing.
  2. bRRD: Relative risk difference = Observed relative risk − 1.