Figure 7

The overexpression of circ_0001971 and circ_0001874 synergistically promoted cell proliferation and suppressed cell apoptosis, while the overexpression of miR-186 and miR-296 obstructed the above effects. (A) Proliferation indicated by OD value at 570 nm was most increased in the hsa_circ_0001874 + hsa_circ_0001971 group. Although the proliferation was comparable between the hsa_circ_0001874 group and hsa_circ_0001971 group, the proliferation was the lowest in the NC group. Moreover, the up-regulation of miR-186 and/or miR-296 suppressed cell proliferation promoted by circRNA overexpression; (B) Apoptosis rate was most reduced in the hsa_circ_0001874 + hsa_circ_0001971 group. Although the apoptosis rate was comparable between the hsa_circ_0001874 group and hsa_circ_0001971 group, the apoptosis rate was the highest in the NC group. Meanwhile, the up-regulation of miR-186 and/or miR-296 increased apoptosis rate suppressed by circRNA overexpression (*P value < 0.05 vs. NC group; # P value < 0.05 vs. hsa_circ_0001874 group; **P value < 0.05 vs. hsa_circ_0001874 + hsa_circ_0001971 group).