Figure 4

Transfer of 10MAC vectors to CHO (hprt−/−). (A,D) Phase-contrast (top panel) and fluorescence (bottom panel) micrographs of CHO (10MAC1) and CHO (10MAC3) are shown. Scale bar: 100 μm. (B,C,E) FISH analyses of each 10MAC vector in the CHO (10MAC1), CHO (10MAC2) and CHO (10MAC3) by digoxigenin-labeled mouse Cot-1 DNA. Arrows indicate each 10MAC vector.