Figure 1

Immune checkpoint molecule expression levels are elevated in circulating T-cells derived from patients with vasculitis. (a) Representative gating strategy of T-cell subsets derived from peripheral blood mononuclear cells (PBMCs). (b) Representative histograms of immune checkpoint molecule expression in CD4⁺ T-cells isolated from PBMCs (red line: systemic vasculitis, blue line: cutaneous vasculitis, black line: healthy donors [HD]). Mean fluorescence intensity (MFI) of immune checkpoint molecule expression on CD4⁺ cells. (c) Representative histograms of immune checkpoint molecule expression in CD8⁺ T cells isolated from PBMC (red line: systemic vasculitis, blue line, cutaneous vasculitis, black line: HD). MFI of immune checkpoint molecule expression on CD8⁺ cells. Data indicate mean ± SEM. * p < 0.05.