Table 2 Changes in cardiac baseline hemodynamics after MOTS-c treatment during exercise training.

From: The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats

Indicator

Group C

Group E

Group ME

SW(mmHg·μL)

10,596.7 ± 95.0

192,566.7 ± 5163.7**

72,316.7 ± 2355.2**##

CO (ÎĽL/min)

97,720.0 ± 1766.7

527,100.0 ± 12,802.0**

293,666.7 ± 2608.3**##

EF (%)

62.07 ± 0.88

71.58 ± 2.32**

72.64 ± 3.85**

Ea (mmHg/ÎĽL)

0.5274 ± 0.0056

0.0943 ± 0.0122**

0.0791 ± 0.0050**

Powmax (mmHg·μL/s)

335,366.7 ± 35,355.7

612,166.7 ± 99,006.6**

101,670.0 ± 35,880.0**##

dP/dtmax (mmHg/s)

4263.3 ± 155.8

9038.3 ± 57.0**

9263.3 ± 185.9**

dP/dtmin (mmHg/s)

6686.0 ± 61.0

8323.7 ± 10.5**

6490.7 ± 67.6**##

Tau (ms)

12.27 ± 0.21

11.99 ± 1.39

7.27 ± 0.35**##

  1. *p < 0.05, **p < 0.01, compared to group C. #p < 0.05, ##p < 0.01, compared to group E. (C = Control, E = Exercise training, ME = Exercise training combined with MOTS-c treatment. SW = stroke work, CO = cardiac output, SV = stroke volume, EF = ejection fraction, Ea = arterial elasticity, Powmax = maximum work, dP/dtmax = the maximum rate of increase in left ventricular pressure, dP/dtmin = the maximum rate of decrease in left ventricular pressure, Tau = time constant of isovolumic relaxation).
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