Table 2 Comparison of model performance among the three data sets and statistical approaches. HJ23 had the highest model performance, yet lowest cohort size, while the opposite is true for eICU-CRD. For MIMIC and eICU-CRD, model performance is similar across all three methods. AUROC area under the receiver operator curve. 95% Confidence Intervals are provided in brackets.

From: Understanding critically ill sepsis patients with normal serum lactate levels: results from U.S. and European ICU cohorts

Dataset

Cohort size

Methods

Accuracy

AUROC

eICU

3394

Logistic regression

78.65 (75.56–81.73)

87.36 (84.86–89.86)

Random forest

77.29 (74.13–80.44)

84.36 (81.65–87.11)

Partial least square

77.32 (74.17–80.47)

83.70 (80.93–86.48)

MIMIC

1295

Logistic regression

80.31 (75.47–85.15)

87.41 (83.37–91.45)

Random forest

80.23 (75.38–85.08)

87.11 (83.03–91.19)

Partial least square

79.54 (74.62–84.45)

87.06 (82.97–91.15)

HJ23

172

Logistic regression

97.14 (91.54–100)

98.69 (94.87–100)

Random forest

80.00 (66.55–93.45)

89.87 (79.73–100)

Partial least square

88.57 (77.88–99.27)

97.67 (92.59–100)