Table 2 Validation in iDAR in 3 ICU subgroups.

From: Machine learning identification of specific changes in myeloid cell phenotype during bloodstream infections

Model validation

AUROC

Sensitivity

Specificity

PPV

NPV

Cutoff

iDAR

Group 1 vs. 2 + 3

0.95 (95% CI 0.89–1)

97%

93%

94%

96%

 > 54.5

Group 2 vs. 3

0.85 (95% CI 0.71–0.98)

82%

81%

82%

81%

 > 98.4

MFI CD64 Neutrophils

Group 1 vs. 2 + 3

0.84 (95% CI 0.75–0.94)

70%

83%

82%

71%

 > 4.3

Group 2 vs. 3

0.76 (95% CI 0.59–0.92)

59%

81%

77%

65%

 > 8.5

  1. AUROC, sensitivity, specificity, positive and negative predictive values (PPV, NPV) are shown at the indicated cutoffs. The performance of CD64 MFI on the same cohort is presented for comparison.