Table 1 Clinical characteristics of DST non-suppressors and controls.

From: HPA axis dysregulation is associated with differential methylation of CpG-sites in related genes

 

DST non-supressors

Controls

Statistics (t-test, Kruskall-Wallis, Chisq.test), P value

N

20

73

 

Age (years)

37.4 (12.1)

39 (11.6)

ns

Men:Women, (n (%))

18 (90) : 2 (10)

69 (5.5) : 4 (5.5)

ns

Diagnosis depression (n(%))

3 (15.0)

6 (8.2)

ns

Hypersexuality (n(%))*

17 (85.0)

43 (58.9)

5.78E-02

CTQ Total

37.2 (13.4)

37.8 (11.2)

ns

TSH (mE/L)/T4 (nmol/L)

0.017 (0.0099)

0.023 (0.02333)

ns

HBA1C (mml/mol)

31.7 (2.9)

33.2 (5.5)

ns

Cortisol (nmol/L)

515.2 (147.2)

458.5 (133.5)

ns

DST Cortisol (nmol/L)

225.8 (92.5)

50.6 (34.2)

5.74E−11

ACTH (pmol/L)

5.94 (2.32)

6.23 (3.19)

ns

DST ACTH (pmol/L)

3.17 (1.79)

1.45 (1.08)

3.37E−05

Testosteron (nmol/L)

13.9 (4.1)

14.1 (5.7)

ns

TNF-alpha (ng/L)

6.9 (2.1)

6.7 (2.2)

ns

IL-6 (ng/L)

2.03 (0.12)

2.30 (0.98)

ns

  1. Values are shown as mean (SD) unless otherwise specified. P-values were calculated by means of t-test, Kruskall-Wallis’ test or chi-squared tests, contrasting values for DST non-suppressors and controls (DST suppressors). A one-tailed p-value < 0.05 was considered significant.
  2. CTQ childhood trauma questionnaire, DST ACTH ACTH levels after the dexamethasone suppression test, DST Cortisol cortisol levels after the dexamethasone suppression test; DST non-suppressors, non-suppression status defined as DST cortisol levels ≥ 138 nmol/l, ns not significant.
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