Table 2 Methylation/transcription correlations of HPA-axis associated CpG sites differentially methylated by DST non-suppression status and positively correlated with DST cortisol levels.

From: HPA axis dysregulation is associated with differential methylation of CpG-sites in related genes

Gene

Transcript

Illumina ID

FTO-cohort (n = 11)

E-GEOD-49065 (n = 10)

Robust linear regression

Pearson correlation analyses

Robust linear regression

Pearson correlation analyses

Coef

P.val

Coef

P.val

Coef

P.val

Coef

P.val

NR3C1

AJ877169

cg07733851

0.53

6.56E-04

ns

ns

ns

NR3C1

AJ877169

cg27122725

ns

ns

0.47

4.04E-02

ns

  1. The table lists CpG-sites located within the TSS2000 of HPA-axis genes with significant cortisol post DST-associated methylation changes. These methylation probes are investigated for a correlation with transcription in two separate cohorts with healthy controls (FTO-cohort and E-GEOD-49065 cohort). Methylation M-values were correlated with expression values inter-individually, by pearson correlations and robust linear regression models, respectively.
  2. Coef. regression coefficient; P.val, P-value.