Table 4 Absolute and relative frequencies of dosage adjustments from standard to reduced dose and from reduced to standard dose at first and subsequent prescriptions.

From: Starting dose and dose adjustment of non-vitamin K antagonist oral anticoagulation agents in a nationwide cohort of patients with atrial fibrillation

 

12 months N° (%)

24 months N° (%)

36 months N° (%)

Overall

Switches form standard to reduced dose

Dabigatran (53,689)

1691 (3.15%)

1604 (2.99%)

1567 (2.92%)

4862 (9.06%)

Rivaroxaban (50,737)

2291 (4.52%)

2259 (4.45%)

2144 (4.23%)

6694 (13.19%)

Apixaban (38,966)

1662 (4.27%)

1536 (3.94%)

1422 (3.65%)

4620 (11.86%)

Switches form reduced to standard dose

Dabigatran (53,689)

805 (1.5%)

660 (1.23%)

646 (1.2%)

2111 (3.93%)

Rivaroxaban (50,737)

614 (1.21%)

621 (1.22%)

722 (1.42%)

1957 (3.86%)

Apixaban (38,966)

707 (1.81%)

761 (1.95%)

731 (1.88%)

2199 (5.64%)