Figure 2 | Scientific Reports

Figure 2

From: The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response

Figure 2

C. albicans activates common TLR- and IFN-associated genes in peripheral blood leukocytes. (a) The upper plot displays the number (set size) of DEGs present in each dataset (y-axis: WBCs, GSE65088, and GSE114180; PBMCs: GSE42606 and GSE154911) and their intersections. Black bubbles, present in rows, mark the dataset, which refers to the amount present in the blue columns, with intersections between two or more groups being shown. (b), Hierarchical clustering of the 44 common DEGs demonstrating gene expression patterns across different studies. The size and color of circles correspond to − Log10 transformed adjusted p value and Log2-fold change (Log2FC), respectively. Blue represents downregulated DEGs, and red indicates upregulated DEGs. The cutoff applied to identify the down/upregulated genes was Log2FC <  − 1/ > 1 and adjusted p value < 0.05. Rows and columns were clustered based on cosine similarity between Log2FC values. (c), GOplot of selected immunological pathways and associated genes. (d), Heatmap of common and specific latent factors across studies. Heatmaps contain genes presenting positive and negative loadings ranging from − 1 to 1. DEGs, differentially expressed genes; PBMCs, peripheral blood mononuclear cells; WBCs, white blood cells.

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