Figure 3

C. albicans activate common TLR and IFN signaling pathways across different leukocyte populations. (a–c), Proportional Venn diagrams displaying the number of DEGs present in each dataset grouped by cell type and their intersections: datasets of WBCs (a), PBMCs (b), and moDCs (c). (d), The intersection plot highlights the number of common DEGs across different cell groups (Venn diagrams were created using CorelDraw2019, available at coreldraw.com). (e), Hierarchical clustering exhibiting pathways enriched in common biological processes across studies (Suppl. Table S10). (f) Further analysis of TLR- and IFN-associated pathways. In both heatmaps, the size of the circles corresponds to the adjusted p value transformed into -Log10, and the color intensity indicates the number of genes in each biological process and pathway across studies. (g) Network demonstrating interactions between TLR- and IFN-associated DEGs/signaling pathways with other molecules and signaling cascades classically associated with antifungal immune responses. Enrichment analysis was performed using Reactome. Circular nodes represent pathways, and their size denotes the number of genes enriching the pathways. Colored squares represent the cellular location of genes. Genes interacting with more than 5 pathways are named. The interaction network was built using NAViGaTOR software. DEGs, differentially expressed genes; moDCs, monocyte-derived dendritic cells; IFN, interferon; PBMCs, peripheral blood mononuclear cells; TLR, Toll-like receptor; WBCs, whole Blood Cells.