Figure 4

Relationship between molecules associated with TLR and IFN signaling cascades. (a) and (b), Correloplot of DEGs associated with TLR and IFN signaling cascades in PBMCs (GSE42606) in the (a), absence or (b), presence of C. albicans. Histograms of Pearson’s correlation coefficient, containing negative and positive correlations from 1 to − 1, respectively. (c) Estimated correlations of TLR- and IFN-associated DEGs versus their corresponding first 2 canonical variates (x-CV1 and x-CV2 for IFN-associated genes; y-CV1 and y-CV2 for TLR-associated genes). Gray-colored variables (with names omitted) are those with correlation coefficients ≤ 0.7 in two corresponding canonical variates. Inner dotted lines limit the canonical correlation coefficient between − 0.7 and 0.7; outer dotted lines limit the coefficient between − 1 and 1. (d) and (e), PCA was used for stratification analysis of resting and C. albicans-infected PBMCs based on TLR- and IFN-associated DEGs. (d), Of note, individuals with similar expression values for these DEGs are grouped together; (e) Variables with positive correlation are pointing to the same side of the plot; negatively correlated variables point to opposite sides. DEGs, differentially expressed genes; IFN, interferon; PBMCs, peripheral blood mononuclear cells; TLR, Toll-like receptor.