Figure 5
available at coreldraw.com). (c), Circular heatmaps of RNAseq expression z-scores computed for log2 transformed DEGs (p value adj < 0.05, fold change > 1 and < − 1) compare expression of TLR (left panels) and IFN (right panels) signaling pathways induced by C. albicans (green/gray heatmaps) or C. auris (yellow/gray heatmaps) all from GSE154911. Small circular heatmaps (blue/gray) demonstrate common DEGs modulated by C. abicans and C auris. Individual circular heatmaps were created using the R packages circlize and ComplexHeatmap; the figure layout was edited using CorelDraw2019. (d), Venn diagram showing the transcriptional overlap (an intersection containing 237 shared DEGs) induced by C. auris and C. albicans (those 1096 genes found across all studies: Suppl. Table S11). (e), Dotplot of enriched signaling pathways by the 237 shared DEGs. DEGs, differentially expressed genes; IFN, interferon; ORA, overrepresentation analysis; TLR, Toll-like receptor.
Induction of interplay between TLR and IFN signaling pathways by other Candida species. Venn diagram showing the transcriptional overlap between (a), TLR- and (b), IFN-associated DEGs and the signaling pathways enriched in response to nonalbicans Candida species (C. glabrata, C. parapsilosis, and C. tropicalis) in comparison to C. albicans (created using CorelDraw2019,
