Figure 6
available at coreldraw.com) of interferon types associated with the group of 1096 DEGs. Interferome analysis revealed 878 IFN-regulated genes modulated by IFN types I, II, and III, as shown in the Venn diagram. DEGs, differentially expressed genes; IFN, Interferon; IEIs, inborn errors of immunity; TLR, Toll-like receptor.
The interactome of DEGs enriched in signaling pathways involved in the anti-Candida immune response and its association with inborn errors of immunity. (a), Relationships (edges) among the 1096 DEGs (nodes) found across all studies (Suppl. Table S11). Subnetworks (semicircles) represent genes associated with IEI causing increased susceptibility to candidiasis; 34 purple node genes are shared with the group of 1096 DEGs, and 66 green nodes represent those not found in the Candida datasets. Blue nodes are highlighted genes with more than 200 partners of interaction. Colored squares and circles represent the cell location of genes. The interaction network was built using NAViGaTOR software. (b), Network of hubs present in (a). (c), Proportional Venn diagram (created using CorelDraw2019,
