Figure 2
From: The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design
(A) AAI-profiler scatterplot. Shown are UniProt species with greater than 40% average amino-acid identity to the Balamuthia ‘main’ proteins. The species name of the top three proteomes with the largest fraction of matches to Balamuthia are indicated. (B) Venn diagram showing the overlap between orthologous cluster groups in the proteomes of B. mandrillaris, A. castellanii and D. discoideum. Total numbers of B. mandrillaris proteins in each group are in parenthesis. (C) Neighbor-joining tree illustrating the phylogenetic relationships between the proteomes of B. mandrillaris and closest species. The tree is based on alignment-free comparisons of the closest complete proteomes detected by AAI-profiler with three Naegleria species as outgroups.
