Figure 4
From: The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design
Sequence conservation of glucokinase in 3 pathogenic amoebas. Potential mis-assembly of the A. castellanii glucokinase (AmoebaDB ACA1_177380) highlighted on a multiple sequence alignment with the B. mandrillaris validated sequence (this study) and N. fowleri crystal structure (PDB: 6DA0)15; helical regions are annotated as pink tubes and beta-sheets as yellow arrows. The alignment was obtained with T-Coffee-Expresso27. The double-stranded beta-sheet missing in A. castellanii glucokinase is colored in red on the active site of the B. mandrillaris structure (PDB: 6VZZ).
