Figure 5
From: The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design
Top: Domain arrangement in human, A. castellanii and B. mandrillaris GART. Domains are annotated as large arrows on the alignment and higher level of residue conservation is represented as darker shades of gray. The region validated by direct sequencing in Balamuthia is underlined with a red squiggle. Secondary structure elements from human GART crystal structures are taken from UniProt. Bottom: Alignment of the GARTFase domains extracted from the GART sequences above.
