Figure 3 | Scientific Reports

Figure 3

From: Ventilatory responses during and following hypercapnic gas challenge are impaired in male but not female endothelial NOS knock-out mice

Figure 3

Panels (A) and (B) Minute Ventilation (MV) values before, during a hypercapnic (HC) gas challenge (5% CO2, 21% O2, 74% N2) and upon return to room-air in male (M) and female (F) wild-type (WT) and eNOS knock-out (eNOS-/-) mice. Panels (C) and (D) Arithmetic changes in MV in male and female WT and eNOS-/- mice during the first 90 s of exposure to the HC challenge and the first 90 s upon return to room-air. Panel (E) Total changes in MV in male and female WT and eNOS-/- mice during the HC challenge and during the first 5 min (RA5) and entire 15 min (RA15) return to room-air. The data are presented as mean Âħ SEM. *P < 0.05, significant change from pre-values. †P < 0.05, eNOS-/- versus WT within each sex.

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