Figure 2 | Scientific Reports

Figure 2

From: Regeneration of collagen fibrils at the papillary dermis by reconstructing basement membrane at the dermal–epidermal junction

Figure 2

The effect of MMP inhibitor and heparinase inhibitor on the accumulation of collagen fibrils in the organotypic human skin model. Immunostaining of type I procollagen (A, B) and type V collagen (C, D), and transmission electron microscopy images (E, F) of organotypic human skin model in the presence of MMP inhibitor CGS27023A and heparinase inhibitor BIPBIPU (B, D, F) as compared with the control (A, C, E). The distribution (G), density (H) and diameter (I) of collagen fibrils were analyzed by WINROOF 2015. White bars in D: 50 μm. White bar in F: 500 nm. Data are expressed as mean ± SD of three independent experiments using samples from six donors. * p < 0.05, ** p < 0.01.

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