Figure 2

The 0D lumped parameter circuital scheme of a kth generic coronary distal circulation and microvasculature. The scheme allows for the subdivision among myocardial layers (index j) and compartments (index i). Acronyms EPI, MID and ENDO stand for subepicardium, midwall and subendocardium, respectively, whereas an arterial, an intermediate and a venous compartment may be identified. Zca and Zcv represent input and output impedances of each district, Ri,j and Ci,j are the resistance and compliance parameter assigned to each i-th compartment belonging to the j-th layer, and pjim is the external forcing intra-myocardial pressure. Qter_art,k, Qout, Qa, Qv, Qca, Qcv, Qja, Qjm, Qjv, Qij, pter_art,k, pout, pa, pv and pij are the hemodynamic variables associated with each single branch or node of the considered coronary district.