Table 1 Clinical and biochemical features of all patients with secondary adrenal insufficiency divided into normal glucose tolerance (NGT) and glucose metabolism disorders (diabetes mellitus, DM, and prediabetes, preDM).

Male

23 (38.3%)

12 (28.5%)

Female

37 (61.6%)

30 (71.4%)

Family history of diabetes

11 (18.3%)

17 (40.4%)

Hypertriglyceridemia

18 (29%)

10 (45.5%)

Hypercholesterolemia

5 (8.3%)

9 (21.4%)

Visceral obesity

50 (83.3%)

32 (76.1%)

Arterial hypertension

7 (11.6%)

9 (21.4%)

Hypothyroidism

44 (73.3%)

35 (83.3%)

Hypogonadism

39 (65%)

25 (59.5%)

GH deficiency

25 (41.6%)

18 (42.8%)

Hydrocortisone replacement therapy

32 (53.3%)

18 (42.8%)

Cortisone acetate replacement therapy

28 (46.6%)

24 (57.1%)

High steroid replacement therapy

25 (41.6%)

24 (57.1%)

Age (years)

Duration of replacement therapy (years)

BMI (Kg/m²)

WC (cm)

Dose of cortisone acetate

Dose of hydrocortisone

Total cholesterol (mmol/l)

HDL cholesterol (mmol/l)

LDL cholesterol mmol/l)

Triglycerides (mmol/l)

Fasting glucose (mmol/l)

Fasting insulin (UI/ml)

GOT (U/L)

GPT (U/L)

Homa 2-IR

AUC_{2h glucose}

AUC_{2h insulin}

ISI Matsuda

Oral Disposition Index (DIo)*

HbA1c (%)

VAI