Table 1 Mean growth rate µ, production rate rp, cell-specific production rate qp, space–time yield STY and maximum product concentration Cpmax for the batch processes (n = 3) and the 55-h steady-state phase of the perfusion process with a macrosparger. Literature data for stable Sf-9 cell lines converted to the units used herein are shown in bold.

From: Process intensification for the continuous production of an antimicrobial peptide in stably-transformed Sf-9 insect cells

 

This article

Literature

Batch (n = 3)

Perfusion

Batch

Perfusion

Sources

µ (1/h)

0.0271 ± 0.0005

0.0248

0.013–0.037

0.015–0.025

35,38,39,40,41

rp (mg/h)

0.0327 ± 0.0144

0.0917

n.a

0.375

33

qp [mg/(ccell × h)]

2.49 × 10–12 ± 3.67 × 10–13

4.17 × 10–12

n.a

8.3 × 10–12

33

STY [mg/(L × h)]

0.0173 ± 0.0076

0.0459

n.a

0.25

33

Cpmax (mg/L)

1.9887 ± 0.5093

0.9077

n.a

5.0

33

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