Figure 1

Expected clock gene rhythm advance in response to ALAN. Schematic shows ALAN effects on transcript levels of BMAL1 measured at midnight (blue) and mid-day (yellow). (A) Rhythm of ALAN under dark night shown as green curve; if the gene's rhythm advances (red curves) with increasing ALAN, transcript levels sampled at midnight will drop, whereas those measured at mid-day will rise; horizontal arrows indicate the advance of the BMAL1 peak. (B) The trends of transcripts with increasing ALAN therefore cross for mid-day vs. midnight sampling. This schematic focuses on effects on phase, assuming robust amplitude.