Figure 5 | Scientific Reports

Figure 5

From: Visualization of tumor heterogeneity and prediction of isocitrate dehydrogenase mutation status for human gliomas using multiparametric physiologic and metabolic MRI

Figure 5

MR images and corresponding hematoxylin and eosin (H&E) and immunohistochemistry staining for MRI-guided biopsy targets (circles). (a) IDH mutant glioma for which an area with labels categorized as M, indicating the IDH mutant feature, was biopsied. Expressions of HIF1a, GLUT3, and HK2 are low in the slides from a 5-mm radius sample taken from the MRI-guided biopsy target. (b) IDH wild-type glioma for which an area with labels categorized as W, indicating IDH wild-type feature, was biopsied. Expressions of HIF1a, GLUT3, and HK2 are high.

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