Figure 2 | Scientific Reports

Figure 2

From: Tear proteomics reveals the molecular basis of the efficacy of human recombinant nerve growth factor treatment for Neurotrophic Keratopathy

Figure 2

Tear functional proteomics results after 4 weeks of treatment. (A, B) Downstream analysis comparing proteomics dataset at T4 Vs T0 condition. The most significant downstream were: Inflammation of organ (A) and DNA synthesis (B). (C, D) reported the most significant upstream comparing proteomics dataset at T4 Vs T0 condition: Brain-derived neurotrophic factor (BDNF) (C) and Versican Core Protein (VCAN) (D). Orange or blue shapes represent predicted activation (z-scores ≥ 2.0) or predicted inhibition (z-scores ≤ 2.0), respectively. The color intensity is directly proportional to the significance of the predicted activation or inhibition. The predicted relationship between genes may lead to direct activation (orange solid lines) or direct inhibition (blue solid lines). Instead, red and green shapes represent increased or decreased measurements of identified proteins, respectively (whose fold change value is reported in the figure). Colour key and symbols are reported in the figure.

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