Figure 4 | Scientific Reports

Figure 4

From: Tear proteomics reveals the molecular basis of the efficacy of human recombinant nerve growth factor treatment for Neurotrophic Keratopathy

Figure 4

EVs characterization in tears during rhNGF treatment. (A) Bean plots reporting the distribution of relative numbers of EVs CD171 + (ratio between EVs CD171+ and total EVs) in the comparison between tear samples collected during rhNGF treatment. The polygon shape (in light blue) represents the density trace of each variable, and inside to that, a scatter plot shows all individual measurements for each single NK patient (black lines). * means p-value < 0.05, at the Student’s t-test and/or Mann Whitney U-test. (B) Rank correlation (Spearman’s coefficient of Rank correlation (rho) = 0.71, and p = 0.0001) between the number of EVs CD171+ and EVs 126+ counted and gated in tears samples collected during rhNGF treatment. (C) The CD171/CD126 dot-plot shows the gate identifying the CD171+/CD126+ population of EVs. (D) Rank correlation (Spearman’s coefficient of Rank correlation (rho) = 0.54, and p = 0.0067) between double positive EVsCD171+/CD126+ with EVs CD45+ in tears samples collected during rhNGF treatment.

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