Figure 6 | Scientific Reports

Figure 6

From: Tear proteomics reveals the molecular basis of the efficacy of human recombinant nerve growth factor treatment for Neurotrophic Keratopathy

Figure 6

Representative case of severe NK before and after treatment. Patient with an evident corneal ulcer, evaluated by slit lamp examination and fluorescein staining (A1–B1). Anterior segment OCT shows an important stromal thinning (C1) and in vivo confocal microscopy analysis (IVCM) (D1) evidences a reduced sub-basal nerve fiber density. After 8 weeks of treatment with topical rhNGF, the resolution of the epithelial defect was evident at slit lamp examination and fluoresce in staining (A2–B2), the healing of stromal ulceration was evident at Anterior segment OCT (C2) and IVCM shows an evident increase of subepithelial nerve fiber density together with Dendritic Cells (DCs) at the level of basal epithelium (D2). Yellow arrows show nerve fibers, while red triangles show DCs.

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