Figure 3 | Scientific Reports

Figure 3

From: Bacillus subtilis spores as delivery system for nasal Plasmodium falciparum circumsporozoite surface protein immunization in a murine model

Figure 3

Indirect ELISA quantification of IgG subclasses in groups immunized only with rPfCSP and with rPfCSP + SBsKO7. The green horizontal lines correspond to the negative control variation (SBsKO7 1 × 108 and PBS). Each graph represents the quantification of the IgG1, IgG2a, IgG2b, and IgG3 subclasses of the rPfCSP (red line) rPfCSP + SBsKO7 (blue line) mice groups. Each point corresponds to the mean O.D. (450 nm) of each mouse in the groups for the subclasses, in the previously mentioned colors. The significance level considered was p < 0.05. Only IgG2a was not significant when compared to IgG1 and, among the other subclasses, the p value was significant over time.

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