Figure 1

(a) Body weight of Brip1+/− and Brip1+/+ mice between the first (D1) and the last (D22) day of the experiments. Data are presented as mean ± SD; n = 5/treatment/genotype. (b) Ovary to body weight ratio of Brip1+/− and Brip1+/+ mice at the end of the treatment. Data are presented as mean ± SD; n = 5/treatment/genotype; *p < 0.05, **p < 0.01. (c) Image illustrating the differences in the size of the ovaries of Brip1+/− and Brip1+/+ mice treated with the combination of carboplatin and paclitaxel or with NaCl 0.9% (control group) at the end of the treatment.