Table 1 Effect of M-CSF neutralization on blood cells.

From: M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling

Parameter, units

Sham + isotype (n = 6)

Burn + isotype (n = 6)

Burn + anti-M-CSF (n = 6)

Neutrophils, K/µl

0.15 ± 0.03

0.68 ± 0.41*

1.23 ± 0.44#

Monocytes, K/µl

0.03 ± 0.03

0.05 ± 0.03

0.03 ± 0.01

Lymphocytes, K/µl

1.03 ± 0.29

1.06 ± 0.54

1.21 ± 0.50

Platelets, K/µl

826 ± 181

1194 ± 116*

1307 ± 120

Red cells, M/µl

8.64 ± 0.30

8.18 ± 0.21*

8.58 ± 0.32#

Hemoglobin, g/dL

14.10 ± 0.44

12.93 ± 0.12*

13.30 ± 0.42

Hematocrit, %

45.07 ± 1.30

42.22 ± 1.28*

42.95 ± 1.83

MCV, fL

52.17 ± 0.76

51.65 ± 1.24

50.08 ± 0.47#

Reticulocytes, K/µl

281 ± 22

318 ± 33

334 ± 65

IRF-M + H, %

58.0 ± 2.4

69.5 ± 2.8*

66.2 ± 3.7

Low CH retic, %

28.2 ± 3.2

31.5 ± 10.3

46.7 ± 5.7#

Hypo retic, %

9.9 ± 4.7

21.8 ± 9.6*

28.4 ± 3.8

  1. Parameters determined on an automated hematology system are presented as mean ± SD.
  2. Significance, ANOVA p < 0.05 is indicated by * for burn isotype versus sham isotype and #for burn anti-M-CSF versus burn isotype.
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