Table 2 Univariate and multivariate analysis of OS in the patients with chemotherapy and without chemotherapy.

From: Publisher Correction: Association between chemotherapy and prognostic factors of survival in hepatocellular carcinoma: a SEER population-based cohort study

Variables

Non-chemotherapy(n = 546)

Chemotherapy(n = 546)

Univariate analysis

Univariate analysis

Multivariate analysis

Multivariate analysis

N

P value

HR(95%CI)

P value

N

P value

HR(95%CI)

P value

Sex

Female

113

Reference

116

—

Male

433

0.0772

0.847 (0.610–1.175)

0.320

430

0.430

—

—

Age at diagnosis, n (%)

 < 59 years

260

Reference

244

Reference

59–66 years

174

0.0954

1.229 (0.917–1.649)

0.168

173

0.390

1.158 (0.875–1.533)

0.306

66–74 years

112

0.9629

1.032 (0.755–1.409)

0.844

129

0.160

1.175 (0.860–1.607)

0.312

Race

White

369

—

367

—

Black

78

0.772

—

—

77

0.460

—

—

Others

99

0.788

—

—

102

0.510

—

—

AJCC

I

207

Reference

219

Reference

II

204

0.357

1.646 (1.191–2.276)

0.002**

185

0.748

1.356 (0.992–1.855)

0.057

III

89

 < 0.001***

2.502 (1.729–3.620)

 < 0.001***

96

 < 0.001***

1.809 (1.264–2.587)

0.001**

IV

46

 < 0.001***

3.326 (2.203–5.021)

 < 0.001***

46

 < 0.001***

2.479 (1.604–3.833)

 < 0.001***

Tumor size

 < 3.5 cm

255

Reference

249

Reference

3.5–7.2 cm

184

 < 0.001***

1.359 (0.986–1.872)

0.061

184

 < 0.001***

1.523 (1.119–2.072)

0.008**

 > 7.2 cm

107

 < 0.001***

1.989 (1.337–2.957)

 < 0.001***

113

 < 0.001***

2.220 (1.496–3.294)

 < 0.001***

AFP

Negative

159

Reference

172

Reference

Positive

387

0.186

1.038 (0.784–1.375)

0.793

374

0.0499*

1.434 (1.081–1.901)

0.012*

Fibrosis score

F0

130

—

123

Reference

F1

416

0.358

—

—

423

0.046*

1.066 (0.780–1.458)

0.69

Grade

Well differentiated

171

Reference

175

Reference

Moderately differenti- ated

272

0.0941

1.466 (1.092–1.967)

0.011*

279

0.980

1.226 (0.922–1.630)

0.161

Poorly differentiated

96

 < 0.001***

1.947 (1.349–2.809)

 < 0.001***

87

0.00756**

1.578 (1.097–2.269)

0.014*

Undifferentiaed

7

0.045*

3.892 (1.496–10.128)

0.005**

5

0.246

1.732 (0.604–4.968)

0.307

Surgery

No surgery

219

Reference

225

Reference

Hepatectomy

108

 < 0.001***

0.151 (0.100–0.228)

 < 0.001***

105

 < 0.001***

0.361 (0.254–0.514)

 < 0.001***

Hepatectomy and transplant

153

 < 0.001***

0.122 (0.078–0.190)

 < 0.001***

145

 < 0.001***

0.154 (0.098–0.242)

 < 0.001***

Others

66

 < 0.001***

0.431 (0.286–0.650)

 < 0.001***

71

0.004

0.681 (0.479–0.968)

0.032*

Radiotherapy

No

496

Reference

497

Reference

Yes

50

 < 0.001***

0.603 (0.410–0.885)

0.010**

49

 < 0.001***

1.288 (0.878–1.887)

0.195

  1. *Two-sided P values < 0.05. **Two-sided P values < 0.01. ***Two-sided P values < 0.001. OS, overall survival; HR, hazard ratio; CI, coindidence intervals; AJCC, American Joint Committee on Cancer (7th). F0, fibrosis score 0–4, non to moderate fibrosis; F1, fibrosis score 5–6, severe fibrosis and cirrhosis.
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