Figure 2

Z-endoxifen (END) and 4-Hydroxytamoxifen (4HT) concentrations in 16 participants with breast cancer taking tamoxifen 20 mg daily: (a) Distribution of END concentrations in venous blood and in plasma. The means were not significantly different (P = 0.257); (b) Distribution of ratios of plasma to venous blood END concentrations; (c) Distribution of 4HT concentrations in venous blood and in plasma. The means were not significantly different (P = 0.496); (d) Distribution of ratios of plasma to venous blood 4HT concentrations. The longer horizontal lines represent means (of concentrations or ratios), and the shorter horizontal lines represent standards of the mean (SEM).