Table 4 Distribution of disease etiology among new hepatocellular carcinoma cases in each quarter.

From: Trends in hepatocellular carcinoma incident cases in Japan between 1996 and 2019

Etiology

First quarter (1996–2001) n = 4311

Second quarter (2002–2007) n = 5505

Third quarter (2008–2013) n = 5776

Fourth quarter (2014–2019) n = 4955

HBV n = 2997 (14.6%)

579 (13.4%)

853 (15.5%)

889 (15.4%)

676 (13.7%)

HBV + HCV n = 187 (0.9%)

67 (1.6%)

65 (1.2%)

39 (0.7%)

16 (0.3%)

HCV n = 12,019 (58.5%)

3147 (73.0%)

3636 (66.0%)

3233 (56.0%)

2003 (40.4%)

Non-BC n = 5344 (26.0%)

518 (12.0%)

951 (17.3%)

1615 (27.9%)

2260 (45.6%)

P-value

-

P < 0.0001 (vs. First quarter)

P < 0.0001 (vs. Second quarter)

P < 0.0001 (vs. Third quarter)

  1. Data are presented as counts (%).
  2. Non BC=both hepatitis B surface antigen and HCV-antibody negative.