Figure 3 | Scientific Reports

Figure 3

From: Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)

Figure 3

Metformin sensitizes leukemic cells to NK cells. (A) OCI-AML3, NB4 and HL60 AML cell lines were treated with 2 mM metformin for 3 days before overnight incubation at 1:1 effector:target (E:T) ratio with e-NK cells. (B) Different MM cell lines were treated with 2 mM metformin (white bars) for 3 days before overnight incubation at 1:1 E:T ratio with e-NK cells or eCTLs. The specific killing of tumor cells (7-AAD+) was quantified by FACs. UCB-MC stays for Umbilical Cord Blood—Mononuclear Cells. The data represent means ± SD; *p < 0.05, **p < 0.01, Student's t-test compared to control cells or as depicted in the graphic.

Back to article page