Figure 3 | Scientific Reports

Figure 3

From: Characterization of a novel non-steroidal glucocorticoid receptor agonist optimized for topical treatment

Figure 3

In vivo efficacy versus systemic side effects of LEO 134310, CP and BMV in the TPA-induced skin inflammation mouse model. Dose–response curves for effect of CP (a), BMV (b) and LEO 134310 (c) on ear biopsy weight, spleen weight and osteocalcin plasma concentration in the TPA mouse model. All values are normalized to vehicle/TPA controls. Body weight vs. dose (d), blood concentration at 2 h after dosing vs. dose (e) and mRNA levels of Fkbp5 vs ear biopsy weight (f) (R = correlation coefficient). Vehicle, (a) CP, (b) BMV, (c) LEO 134310. Mean values at each dose (n = 2) in (a–e) and individual values in (f).

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