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Figure 1

From: Copy number alterations analysis of primary tumor tissue and circulating tumor cells from patients with early-stage triple negative breast cancer

Figure 1

Copy number alteration (CNA) analysis of TNBC before and after neoadjuvant chemotherapy (NAC). (a) Barplot showing detection of CNA events obtained from all patients in the cohort. X-axis reports the genomic regions present in CCP panel divided by chromosomes while y-axis reports their absolute number of alterations by different sample type. “No events” refers to genomic regions with no alterations detected (b) Top 20 altered genes in the study cohort. The heatmap reports in the columns the pre- and post-NAC samples and in the rows the altered genes by chromosomal arms. Red and blue colors refer to amplification and deletion events respectively. (c) Box plot comparing pre- and post-NAC samples alterations (gain = red, loss = blue) in patients with matched tumors. (d) CNA plot for patients #13 and #14. Vertical lines represents the log2 ratio of gene copy number colored based on its status (amplification = red; deletions = blue).

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