Figure 2 | Scientific Reports

Figure 2

From: Copy number alterations analysis of primary tumor tissue and circulating tumor cells from patients with early-stage triple negative breast cancer

Figure 2

Phylogenetic analysis of patients#27. (a) Dendrogram and heatmap show single cell phylogeny obtained from TRONCO. Dendrogram (left) shows single CTCs colored by clones identified by TRONCO while heatmap (right) details the CNA alterations for each CTCs (rows) along the genes (columns) considered for the phylogenetic analysis. Brown and blue colors refer to amplification and deletion, respectively. (b) Representation of clonal phylogeny along time. the timescape plot (left) reports on Y-axis the prevalence of each clone while the table (right) describes clonal composition. The column “Alteration in clone” show CNAs defined as “priority” (bold) and “secondary” returned by TRONCO for each clone. The term “new” refers to set of clone with no alterations in genes considered for phylogenetic analysis.

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