Table 1 Results of power calculation for the main analysis (using top eQTL).
From: Rho GTPase gene expression and breast cancer risk: a Mendelian randomization analysis
Gene | Resource | Tissue | R2 | F-statistic | Power (overall BC) | Power (ER+ BC) | Power (ER− BC) |
|---|---|---|---|---|---|---|---|
RHOD | GTEx | Breast mammary | 27.28 | 93.42 | > 99 | > 99 | > 99 |
RHOD | eQTLGen | Blood | 0.35 | 107.03 | > 99 | 59.63 | 30.06 |
CDC42 | eQTLGen | Blood | 3.41 | 1118.52 | > 99 | > 99 | > 99 |
CDC42 | TCGA | Breast cancer | 0.31 | 14.97 | 67.57 | 54.56 | 27.19 |
RHOBTB1 | GTEx | Breast mammary | 20.76 | 65.24 | > 99 | > 99 | > 99 |
RHOBTB1 | eQTLGen | Blood | 1.85 | 582.89 | > 99 | > 99 | 91.20 |
RHOBTB2 | eQTLGen | Blood | 0.49 | 154.52 | 86.01 | 74.25 | 39.85 |
RHOU | eQTLGen | Blood | 2.95 | 803.91 | > 99 | > 99 | 98.70 |
RHOU | TCGA | Breast cancer | 0.34 | 16.00 | 70.45 | 57.32 | 28.72 |
RHOQ | eQTLGen | Blood | 1.07 | 257.98 | > 99 | 97.16 | 71.24 |
RHOQ | TCGA | Breast cancer | 0.44 | 21.29 | 82.09 | 69.57 | 36.40 |
RHOH | eQTLGen | Blood | 0.31 | 97.50 | 67.34 | 54.34 | 27.07 |
RHOG | eQTLGen | Blood | 0.65 | 206.04 | 93.78 | 85.14 | 49.93 |
RHOG | TCGA | Breast cancer | 0.35 | 16.90 | 72.78 | 59.63 | 30.06 |
RHOC | eQTLGen | Blood | 1.90 | 609.56 | > 99 | > 99 | 91.90 |
RHOB | eQTLGen | Blood | 0.59 | 188.24 | 91.67 | 81.88 | 46.50 |
RHOB | TCGA | Breast cancer | 0.27 | 12.94 | 61.28 | 48.77 | 24.13 |
RHOJ | TCGA | Breast cancer | 0.54 | 26.11 | 89.01 | 78.13 | 43.04 |
RAC1 | eQTLGen | Blood | 2.03 | 546.86 | > 99 | > 99 | 93.46 |
RAC1 | TCGA | Breast cancer | 0.28 | 13.67 | 63.65 | 50.91 | 25.24 |
RAC2 | eQTLGen | Blood | 2.65 | 863.39 | > 99 | > 99 | 97.77 |
RAC2 | TCGA | Breast cancer | 0.34 | 16.44 | 71.62 | 58.47 | 29.38 |
RND2 | TCGA | Breast cancer | 0.78 | 38.02 | 97.00 | 90.96 | 57.58 |
