Figure 1 | Scientific Reports

Figure 1

From: Sodium–calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer’s disease

Figure 1

Barnes circular maze task for spatial memory test of 4-month-old 5xFAD mice after 45 consecutive days (P30-75) treatment with W. somnifera. Representative heat maps (A), and data that compare the latency time (B) and the average number of error head pokes (C) to enter the escape box during the acquisition training phase. (D) The probe trial time-spent in the target zone to locate the hole which previously contained the escape box. The data represent the mean ± SEM. Data were from 12 different mice in each group (n = 12) using repeated-measures ANOVA (in B, C), two-way ANOVA, one-way ANOVA, Tukey’s multiple comparisons tests. Significance is indicated by *p < 0.05; **p < 0.01; ***p < 0.001 versus vehicle; by †p < 0.05, ††p < 0.01 between W. somnifera treated groups; by ‡p < 0.05, ‡‡p < 0.01 between W. somnifera and Res treated groups; by ^p < 0.05 between days 1 and 5 (in C). Vehicle control group, LDT low dose treatment, HDT high dose treatment, Res Resveratrol.

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