Figure 5 | Scientific Reports

Figure 5

From: Sodium–calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer’s disease

Figure 5

Confocal microscope immunoreactive studies to examine Aβ plaque deposition in the hippocampus region of 4-month-old 5xFAD mice brain after 45 consecutive days (P30-75) treatment with W. somnifera. (A) Representative images at × 100 of combined immunofluorescence and Thioflavin-S staining of the mice brain coronal sections, scale bar = 500 μm. (B) Quantification of the average number of Aβ plaque deposition. (C) Percentage of the area occupied by the plaques. The data represent the mean ± SEM. Data were from 4 different mice in each group (n = 4 of two independent sessions) using one-way ANOVA followed by Tukey’s multiple comparisons test. Significance is indicated by *p < 0.05; **p < 0.01 versus vehicle; by †p < 0.05 between W. somnifera treated groups; by ‡p < 0.05 between W. somnifera and Res treated groups. Vehicle control group, LDT low dose treatment, HDT high dose treatment, Res Resveratrol.

Back to article page