Table 2 Summary of included studies employing short cognitive screening tools to assess cognitive impairment.
Study | Study design | Location | Endocrine therapy use | Sample size | Sample age (range, mean) | Assessment method | Methodological quality | Definition of cognitive decline | Time point(s)ǂ | Prevalence % (95% CIs where available) |
|---|---|---|---|---|---|---|---|---|---|---|
Biglia 201249 | Prospective Longitudinal | Italy | No | 40 | 38–65, 51 | MMSE | Moderate | Score under the mean | T2 | 31 |
Brezden 200025 | Cohort | Canada | Yes | 71 across two groups: (1) Currently receiving chemotherapy, and (2) one year after cessation | 34–70, 49 26–61, 46 | HSCS | High | Classification as mild, moderate or severe according to pattern of scores as described by test authors | T1, T4 | T1 Mild: 13 Moderate: 10 Severe:12/31 = 39 T4 Mild: 20 Moderate: 28 Severe:9/40 = 23 |
Fan 200526 | Cohort | Canada | Yes | 81 | 48 (median) | HSCS | High | Scores from each item on the test were subject to an algorithm which generated bands of impairment | T2,T4,T5 | T2 Mild: 35 Mod-Severe: 16 T4 Mild: 30 Mod-severe: 4 T5: Mild: 21 Mod-severe: 4 |
Fontes 201640 | Prospective longitudinal | Portugal | Yes | 475 | 54.7 (median) | MoCA | High | A MoCA score at least 2.0 standard deviations below age- and education-adjusted cut-offs | T3, T5 | T3: 7 T5: 8 |
Ng 201852 | Prospective Longitudinal | Singapore | Yes | 166 | 50.7 | Headminder computerized test | High | Reliable change index (RCI) score calculated to determine cognitive decline in each cognitive domain. A RCI score of lower than − 1.5 was used as criteria for decline | T1, T3 | T1: 6.1–21.6 T3: 1.2–14.6 |
Pillai 201943 | Prospective longitudinal | India | Yes | 152 | 27–72, 47 | MMSE | Low | MMSE score of ≤ 24 (out of 30) | T2,T3,T4,T5 | T2: 0 T3: 0 T4: 0 T5: 0 |
Prokasheva 201161 | Cohort | Israel | Yes | 20 | 30–57, 49.3 | Doors and people test | Moderate | Below 1SD as indicative of mild impairment and below 2SD for moderate impairment | T5 | 40 |
Ramalho 201762 | Cohort | Portugal | Yes | 418 | 27–87 | MoCA | High | MoCA score values at least 1.5 standard deviations below age- and education-adjusted cut-offs | T3 | 8 (5.8, 11) |
Tchen 200363 | Cohort | Canada | No | 110 | 27–60, 48 | HSCS | High | Based on standard test criteria | T1 | T1 Mild: 34 Moderate: 2 Severe: 14 |
