Table 4 The specificity of ANA titer, the number of positive-AAbs in ANAs and various AAbs for SLE.

From: High titers of antinuclear antibody and the presence of multiple autoantibodies are highly suggestive of systemic lupus erythematosus

 

Sensitivity (%)

Specificity (%)

+ LR

− LR

The area under the ROC curve (Az)

ANA titer

≥ 1 +

96.62

81.29

5.16

0.042

0.954

≥ 2 +

86.49

90.69

9.29

0.15

≥ 3 +

68.24

96.52

19.6

0.33

The number of positive-AAbs in ANAs

≥ 1

93.92

80.42

4.8

0.076

0.933

≥ 2

77.03

94.95

15.26

0.24

≥ 3

50.68*

99.3▲

72.78

0.5

Anti-U1 RNP

41.22

98.0

20.59

0.6

0.705

Anti-Sm

16.89

99.74

64.7

0.83

0.599

AnuA

41.89*

99.74▲

160.45

0.58

0.715

Anti-rRNP

31.76*

99.56▲

72.98

0.69

0.662

AHA

41.89

98

20.95

0.59

0.702

Anti‐dsDNA

13.51

98.87

11.94

0.87

0.567

Anti-SSA

63.51

87.47

5.07

0.42

0.767

Anti-SSB

22.97

97.21

8.25

0.79

0.606

  1. *p < 0.01, compared with anti-Sm. ▲p > 0.05, compared with anti-Sm.
  2. ANA antinuclear antibody, ANAs antinuclear antibodies, AAbs auto-antibodies, SLE systemic lupus erythematosus, + LR the estimated positive likelihood ratio, −LR the estimated negative likelihood ratio, anti-U1RNP anti-U1 ribonucleoproteins, anti-Sm anti-Sm antibody, AnuA anti-nucleosome antibody, anti-rRNP anti-ribosome ribonucleoprotein antibody, anti-dsDNA anti-dsDNA antibody, AHA anti-histone antibody, anti-SSA anti-SSA antibody, anti-SSB anti-SSB antibody.
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